BET Bromodomain Degradation Disrupts Function but Not 3D Formation of RNA Pol2 Clusters
Fusion-positive rhabdomyosarcoma (FP-RMS) is driven by a translocation that creates the chimeric transcription factor PAX3-FOXO1 (P3F), which assembles de novo super enhancers to drive high levels of transcription of other core regulatory transcription factors (CRTFs).P3F recruits co-regulatory factors to super enhancers such as BRD4, which recogni